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期刊《日中医学》

特辑:中日两国免疫抑制药物治疗的现状与课题

前言 免疫抑制药物治疗的现状与展望

爱知医科大学外科学(肾移植外科) 教授
小林孝彰

中国特发膜性肾病免疫抑制剂应用现状和展望

郑州大学第一附属医院肾内科
刘亚飞、邢国兰※1
※1.教授、主任医师(通讯作者)

The Treatment of Idiopathic Membranous Nephropathy by Immunosuppressants in Chinese Mainland


【Abstract】
In Chinese mainland, the incidence of Idiopathic Membranous Nephropathy (IMN) is increasing. If the treatment is not efficient, IMN will gradually progress to end stage renal disease (ESRD). The specific treatment of IMN is mainly immunosuppressive therapies. The review was performed to summarize the application and progress of immunosuppressants for IMN in Chinese Mainland, so as to provide relevant evidences for clinical research and treatment.

【Key words】
Idiopathic Membranous Nephropathy, Immunosuppressants, review, Chinese Mainland

中国血液病应用免疫抑制药物治疗的现状与前景

福建医科大学附属协和医院血液科
付海英、刘彦权

中国中医科学院西苑医院血液科
刘为易、胡晓梅※1
※1.主任医师(通讯作者)

Current Status and Future Insights of the Application of Immunosuppressive Drugs in Hematology in China


【Abstract】
The pathogenesis of hematological diseases is complex. Most of them are usually in critical condition with poor prognosis and difficult clinical treatment. It is a type of diseases that seriously threaten the life and health of Chinese people. In recent years, with the rapid development of basic and clinical research in immunology in the field of hematology, immunotherapy has emerged, and it is expected to improve the efficacy of the hematological diseases treated by traditional therapy. This paper will discuss the current status of the application of immunosuppressive drugs in China, with a view to the prospect of
immunosuppressive drugs in the field of hematology.

【Key words】
Hematological diseases, Blood diseases, Immunotherapy, Immunosuppressive agents

免疫抑制剂与器官保存

旭川医科大学移植医工学治疗开发教研室
松野直徒※1
※1.特聘教授(通讯作者)

旭川医科大学医院消化外科,肝胆胰、移植外科
松野直徒、庄中达也、高桥裕之、萩原正弘、今井浩二、横尾英树、合地美香子、大谷将秀、古川博之

旭川医科大学医院小儿外科
石井大介

首都大学东京医用工学研究室
小原弘道

Current topics of immunosuppression and preservation for organ transplantation


【Abstract】
Genetic substitution, even in the immunosuppression for organ transplantation has been promoting in national health insurance system for Japan. Intensive drug monitoring may be required in genetic substitution, especially in the case of mycofenorate mofetil. Immunosuppressive agents of which TDM monitoring is recommended to optimize the individual dose in the transplant recipients are also required to substitute from original bland to genetic, even though their pharmacokinetics are not equal. The drig monitoring may be required in even genetic MMF. There are two methods for transplant organ preservation in the world; Simple static cold preservation(CS)and machine perfusion preservation(MP). Recently, our research group reported the beneficial effects of human artificial hemoglobin vesicle, (artificial blood)as a preservation solution for MP. This study will promise ex vivo organ treatment including immunosuppression before transplantation.

【Key words】
genetic MMF, organ preservation, ex vivo immunotherapy

日本免疫抑制药物治疗的现状:
以他克莫司TDM 为中心

筑波大学附属医院药剂科
铃木嘉治※1
※1.医院讲师(通讯作者)

筑波大学医学医疗系临床药剂学 教授
筑波大学附属医院药剂科 药剂科长
本间真人

Current issues of immunosuppressive agents for organ transplantation in Japan.
―― TDM for tacrolimus as the typical agent


【Abstract】
Tacrolimus, a calcineurin inhibitor, is an important immunosuppressive agent in organ transplantation. Since many factors affecting tacrolimus pharmacokinetics alter the blood concentration, therapeutic drug monitoring (TDM) is required to adjust the tacrolimus dosage for individual patient. In this review, current use of tacrolimus for organ transplantation in terms of the pharmacokinetics aspects including CYP3A5 genotype, drug-food and drug-drug interaction. Switching the original formulation of tacrolimus to generic ones is also discussed in the clinical practice in Japan.

【Key words】
tacrolimus, pharmacokinetics, generic, genotype, drug-food interaction

 

纽 带 
       
       

与中国开展核灾害医疗的交流以及核风险防护研究的开端
福岛县立医科大学 副校长、理事长特別助理
(长崎大学名誉教授)
山下俊一

笹川生 in China 
     
     

在琉球大学邂逅的温暖
中日友好医院放射诊断科 主治医師
徐妍妍

News Letter
〜日中医学协会资讯〜
      
      

日中医学协会迎来2020 年度
日中医学协会 理事长
小川秀兴
 
中日笹川医学奖学金项目第43 期研究员选拔工作的通知

后 记 宣传委员会委员  平野俊彦
期刊《日中医学》一般投稿征稿通知