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巻頭言 薬学領域からみた感染症治療の現状と課題

国立国際医療研究センター 国際感染症センター長


済寧医学院附属病院院内感染管理部 副主任医師
中南大学湘雅病院院内感染制御センター 主任医師

Monitoring of Therapy Drug Monitorin(TDM) and Multidrug-resistant Organisms in Clinical Practice for Infection Control

The widespread use of broad-spectrum antimicrobials has led to the emergence of multidrug-resistant organisms(MDRO), which bring severe challenges to clinical treatment and control of infections. MDRO infection is a critical threat, and the prevention and control of healthcare-associated infection(HAI)require multi-sectoral cooperation; the most important is in rationally using and managing antimicrobial agents. From a pharmacological perspective, this includes determining the following: the right patient, drug, time, dose, and route. Therapeutic drug monitoring(TDM)can assist the rational adjustment of antimicrobial dose in clinical settings.

【Key words】
Multidrug-resistant organisms, Healthcare-associated infection, Therapeutic drug monitoring, MDRO, HAI, TDM


孔維華 馮佳佳 林麗開※1
※1 教授/常任副所長(責任著者)

Status of Antimicrobial Administration and Antimicrobial Resistance in China

The Chinese government started advocating the rational use of antibiotics 20 years ago, and it is one of the first countries in the world to issue and implement a national action plan for curbing antibiotic resistance. This paper reviews the core strategies and main practices of the Chinese government in the management of antibiotics at different stages, and it briefly describes and analyzes the current situation of antibiotic resistance in China.

【Key words】
Chinese pharmaceutical policy, Antibiotics management, Rational drug use, Bacterial resistance


順天堂大学医学部附属順天堂医院 薬剤部長
順天堂大学薬学部開設準備室 客員教授
日本化学療法学会 抗菌化学療法認定薬剤師制度委員会 委員長

Applications of Pharmacometrics in the Prevention of Antimicrobial Resistance and MIPD

The team approach of the infection control team(ICT) and the antimicrobial stewardship team(AST) contributes to the prevention of antimicrobial resistance. The activities of ICT and AST are defined as the health insurance system in Japan. The role of pharmacy services is especially important in AST. A board-certified system of infectious diseases and antimicrobial stewardship pharmacists have been established by The Japanese Society of Hospital Pharmacists and the Japanese Society of Chemotherapy.

【Key words】
AMR, PK/PD, MIPD, Pharmacometrics, TDM


塩野義製薬株式会社創薬疾患研究所 感染症領域シニアフェロー

Development and Prospects of Anti-AMR Drugs from Japan

Antimicrobial resistance(AMR)is a significant issue for global health due to the increase in resistance and the decrease in newly-approved antimicrobials. The lack of development of new antibiotics against carbapenem-resistant Gram-negative bacteria is one of the most significant issues. The current status and action plan for developing new antibiotics and tackling AMR, and the role of Japan in these are described.

【Key words】
Carbapenem resistant Gram-negative bacteria, Beta-lactamase inhibitors, Siderophore beta-lactam antibiotic, Action plan on AMR



- 1981 年から2021 年の研究の分析 -

Research Trends Focusing on the Health Issues of Chinese Returnees and
Their Families
– The Analysis of Studies Between 1981 and 2021 –

医療創生大学国際看護学部 教授(責任著者) 安田真奈美
医療創生大学国際看護学部 助教  佐藤鳳玲
東京武蔵野病院 看護師  天谷史樹
横浜創英大学看護学部 教授  小林貴子

笹川生 in China

Everything for sick children is OK
湖南省児童病院肝移植科 副主任医師   陳立健

あとがき 広報委員会委員  袁 博、山田陽城